Fig. 3: Significant enrichment of genes mapped to SNPs of depression risk loci of the female protective cluster, in gene sets of C2 curated, C5 GO BP, and C5 GO MF gene set collections; and genes mapped by either eQTL association (green) or chromatin interaction (orange), to this cluster’s depression risk loci (blue) on chromosome 12. | Translational Psychiatry

Fig. 3: Significant enrichment of genes mapped to SNPs of depression risk loci of the female protective cluster, in gene sets of C2 curated, C5 GO BP, and C5 GO MF gene set collections; and genes mapped by either eQTL association (green) or chromatin interaction (orange), to this cluster’s depression risk loci (blue) on chromosome 12.

From: Olfactory genes affect major depression in highly educated, emotionally stable, lean women: a bridge between animal models and precision medicine

Fig. 3

A–C Our mapped genes, as well as their proportion within each gene set, and p-value of their enrichment in each gene set are shown. Benjamini–Hochberg FDR correction was applied within each gene set category, and the adjusted p-value cutoff was p < 0.0125 because of the four clusters. Only results surviving correction are shown. D Top SNP of each risk locus is named, and all SNPs are shown as dots on a −log10p-value axis and in their chromosomal position, with red dots representing an R2 > 0.8 and orange dots an R2 > 0.6 linkage with the top SNP. OR6C74, OR6C3, OR6C75, and OR6C4 are the mapped odorant receptor genes that show a significant enrichment in olfactory gene sets. SNP single-nucleotide polymorphism, GO Gene Ontology, BP biological process, MF molecular function, eQTL expression quantitative trait locus, FDR false discovery rate.

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