Table 2 Serum concentrations of neurotrophins and their respective gene expressions in the morning after polysomnographic examination and sleep deprivation.
All | Respondents | Non-respondents | |||||||
|---|---|---|---|---|---|---|---|---|---|
PSG morning n; median IQR | DS morning n; median IQR | p | PSG morning n; median IQR | DS morning n; median IQR | p | PSG morning n; median IQR | DS morning n; median IQR | p | |
BDNF protein | 80; 4043,8 (1337.4–8247.0) | 81; 3799.6 (1789.6–7972.7) | 0.625 | 49; 3871.8 (1417.7–8810.4) | 50; 3905.4 (1789.6–9068.9) | 0.731 | 31; 4330.5 (947.3–7534.4) | 31; 3607.3 (1588.1–7972.7) | 0.829 |
GDNF protein | 79; 66.5 (9.7–485.7) | 80; 52.2 (14.0–496.6) | 0.214 | 49; 45.7 (9.6–293.1) | 50; 42.9 (16.6–384.0) | 0.717 | 30; 98.0 (14.4–711.1) | 30; 64.5 (7.8–665.3) | 0.030 |
NT-3 protein | 80; 102.5 (93.1–109.8) | 81; 143.4 (131.5–165.7) | <0.001 | 49; 100.7 (92.8–109.7) | 50; 143.3 (133.5–166.2) | <0.001 | 31; 104.2 (93.5–110.6) | 31; 143.4 (131.0–162.3) | <0.001 |
NT-4 protein | 80; 3273.0 (1627.6–5128.5) | 81; 4868.7 (3048.5–6452.5) | <0.001 | 49; 3097.3 (1457.3–5764.0) | 50; 5025.3 (2393.1–7246.6) | 0.001 | 31; 3420.2 (2712.7–4889.0) | 31; 4701.0 (3665.7–5945.2) | 0.013 |
BDNF mRNA | 75; 1117.3 (358.5–1438.9) | 76; 165.6 (34.4–617.8) | <0.001 | 47; 1117.3 (380.2–1414.2) | 47; 143.1 (33.7–628.5) | <0.001 | 28; 1119.2 (263.8–1508.5) | 29; 179.9 (50.6–607.1) | 0.002 |
GDNF mRNA | 75; 768.4 (334.5–1117.3) | 76; 344.5 (117.5–917.1) | 0.017 | 47; 768.4 (430.8–1121.2) | 47; 341.5 (103.3–864.5) | 0.006 | 28; 795.0 (240.4–1117.3) | 29; 407.5 (131.7–1042.5) | 0.554 |
NT3 mRNA | 75; 704.7 (308.9–1064.4) | 75; 447.5 (115.0–820.7) | 0.040 | 47; 704.7 (407.5–1064.4) | 46; 471.2 (132.6–779.2) | 0.005 | 28; 624.3 (244.59–1072.19) | 29; 357.3 (115.0–858.6) | 0.981 |
NT4 mRNA | 75; 2848.1 (1136.8–6821.1) | 76; 2220.4 (551.0–7298.0) | 0.392 | 47; 2732.1 (1438.9–8282.1) | 47; 1925.2 (491.4–8083.6) | 0.397 | 28; 3759.2 (798.1–6109.5) | 29; 2488.0 (823.6–5521.3) | 0.699 |
