Fig. 1: Effects of MT on cell viability, cell morphology, and ultrastructure in HAPI cells treated by CORT. | Translational Psychiatry

Fig. 1: Effects of MT on cell viability, cell morphology, and ultrastructure in HAPI cells treated by CORT.

From: Melatonin alleviates chronic stress-induced hippocampal microglia pyroptosis and subsequent depression-like behaviors by inhibiting Cathepsin B/NLRP3 signaling pathway in rats

Fig. 1

A HAPI cells viability after treatment with different concentrations of CORT. B HAPI cell viability after treatment with different concentrations of MT. C The effect of 75 and 100 μM MT on the cell viability of 40 μM CORT-treated HAPI cells. D The representative morphology images of HAPI cells; 200× magnification; scale bars = 100 µm. The red thick-tailed arrows indicate that some cells have been deformed and are fusiform. The red thin-tailed arrows indicate that some cell membranes have broken. E The representative ultrastructural images of HAPI cells. See the lower left corner of each picture for specific magnification; Scale = 2 μm or 1 μm. The red “N” indicates nucleus. The red triangle represents normal organelles (mitochondria, Golgi bodies, etc.) in the cytoplasm. The red thin-tailed arrow indicates mitochondrial cavitation. All data are presented as the mean ± SD (n = 6). *P < 0.05 and **P < 0.01 versus 0 μM CORT and 0 μM MT group. ##P < 0.01 versus 40 μM CORT and 0 μM MT group.

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