Table 2 EWAS DMP and DMR analyses of treatment responders at T2 (pre-treatment) vs T2 (post-treatment).

From: Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder

a: EWAS DMPs identified in the treatment responders at T2 compared with T1.

Responders T1 VS T2

Gene

Probe

Chr

Position

m-value

FDR

Log Beta

Delta Beta

PHF15

cg07525804

5

133914473

3,83E + 07

0.2293

1,21E + 09

0.0368

HMBS

cg27472151

11

118956135

5,91E + 07

0.2293

1,63E + 09

0.0211

ARHGEF10

cg14861020

8

1772352

1,03E + 08

0.2656

3,72E + 09

0.0258

 

cg18890561

10

131988419

1,69E + 07

0.3276

8,21E + 09

0.0494

RAB27A

cg24809382

15

55582033

3,33E + 08

0.3930

0.0002

0.0070

b: EWAS DMRs identified in the treatment responders at T2 compared with T1.

Responders T1 VS T2

Gene

Chr: start-end

Area

L

Cluster (L)

p-value

FWER

Direction

ARSG

6: 291687-293285

0.557796234341063

7

7

3.15E-4

0.48

T2 > T1

SOX2OT

17:6899207-6899577

0.540558928908835

8

20

3.13E-4

0.86

T2 > T1

BIN2

10:12335523-123356041

0.514183280465409

7

14

3.98E-4

0.91

T2 > T1

PARVB

3:1954890-195490033

0.490337023581752

7

9

4.49E-4

0.91

T2 > T1

LGR6

17:80545175-80545434

0.446370934234037

5

6

5.34E-4

0.98

T2 > T1

  1. Top 5 Responders vs. non responders at T2 (post-treatment). DMPs: Differently methylated positions Genome build (HG19), Gene: UCSC Reference Gene Name, chr: chromosome; m-value; FDR: false discovery rate adjusted p-value (Mval); LogBeta and DeltaBeta: delta differences between groups, based on average β-values.
  2. Top 5 DMRs of association analyses of 1) Responders vs. non responders at T2 (post-treatment). DMRs Differently methylated regions Detected DMRs (L > 1) using Bumphunter; Genome build (HG19), Gene: UCSC Reference Gene Name, chr:start-end chromosome and position, area area bump, L Number of probes in DMR; cluster(L): number of probes in cluster; FWER Family-Wise Error Rate.
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