Fig. 1: Pathways differently modulated in adolescents with current major depressive disorder (MDD) compared with adolescents at high risk (HR) for future depression (both males and females). | Translational Psychiatry

Fig. 1: Pathways differently modulated in adolescents with current major depressive disorder (MDD) compared with adolescents at high risk (HR) for future depression (both males and females).

From: Inflammation and immune system pathways as biological signatures of adolescent depression—the IDEA-RiSCo study

Fig. 1: Pathways differently modulated in adolescents with current major depressive disorder (MDD) compared with adolescents at high risk (HR) for future depression (both males and females).

For graphical purposes, only pathways with z-scores ≥2 or ≤−2 are plotted on this figure; pathways colored in orange represent a z-score ≥2, which means a predicted activation of that pathway in MDD adolescents compared with HR adolescents. On the other hand, pathways colored in blue represent z-scores ≤−2, which means a predicted inactivation of that pathway in MDD adolescents compared with HR adolescents. Pathways without the z-score have not been reported in the figure but are reported in Supplementary Table S3.

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