Fig. 4: Pathways differently modulated in female adolescents with current major depressive disorder (MDD) compared with the high risk (HR) female group.

For graphical purposes, only pathways with z-scores ≥2 or ≤−2 are plotted on this figure; pathways colored in orange represent z-scores ≥2, which means a predicted activation of that pathway in MDD adolescents compared with HR adolescents. On the other hand, pathways colored in blue represent z-scores ≤−2, which means a predicted inactivation of that pathway in MDD adolescents compared with HR adolescents. Pathways without a z-score have not been reported in the figure but are reported in Supplementary Table S6.