Fig. 2: Estimated marginal means of the timepoint x compound interaction on spontaneous brain activity in subregions of the anterior cingulate cortex (ACC).

A Subgenual ACC; B pregenual ACC; C dorsal ACC. The calculated ANCOVAs included the baseline activity of the respective subregion as a covariate. Stars depict the results of the calculated post-hoc comparisons. *p < 0.05; **p < 0.01; ***p < 0.001. PK placebo-ketamine group, LK lamotrigine-ketamine group, PP placebo-placebo group.