Fig. 5: Effect of a selective GluN2A-containing NMDA receptor antagonist PEAQX (10 μM) on facial stimulation-evoked MF-GC synaptic transmission in VPA-exposed mice. | Translational Psychiatry

Fig. 5: Effect of a selective GluN2A-containing NMDA receptor antagonist PEAQX (10 μM) on facial stimulation-evoked MF-GC synaptic transmission in VPA-exposed mice.

From: Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice

Fig. 5

A Representative traces showing that paired air-puff stimulation (10 ms, 60 psi) of the ipsilateral whisker pad evoked MF-GC synaptic transmission in control and VPA mice treated with ACSF or PEAQX (10 μM) or subjected to washout. Mean (±S.E.M) of the amplitude (B) and half-width (C) of N1 in mice treated with ACSF or PEAQX or subjected to washout. Mean (±S.E.M) of the amplitude (D) and area under the curve (E) of N2 in mice treated with ACSF or PEAQX or subjected to washout. n = 8 in each group. *P < 0.05, PEAQX versus ACSF; #P < 0.05, VPA versus control.

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