Fig. 1: Minocycline and PLX3397 reverse Aβ-mediated LTP impairment. | Translational Psychiatry

Fig. 1: Minocycline and PLX3397 reverse Aβ-mediated LTP impairment.

From: Switch to phagocytic microglia by CSFR1 inhibition drives amyloid-beta clearance from glutamatergic terminals rescuing LTP in acute hippocampal slices

Fig. 1

A On the left, superimposed pooled data showing LTP in slices treated with Aβ1–42 (n = 8) or Aβscrambled (n = 8). On top, representative traces for both conditions are shown. On the right, histograms illustrating the magnitude of LTP (% of baseline) in the two experimental conditions. B On the left, superimposed pooled data showing LTP in slices treated with Aβ1–42 (n = 8), Aβ1–42 +minocycline (n = 8) or Aβscrambled+ minocycline (n = 6). On top, representative traces for both conditions are shown. On the right, histograms illustrating the magnitude of LTP (% of baseline) in the different experimental conditions. C On the left, superimposed pooled data showing LTP in slices treated with Aβ1–42 (n = 8), Aβ1–42 + PLX (n = 7) or Aβscrambled + PLX (n = 7). On top, representative traces for different experimental conditions are shown. On the right, histograms illustrating the magnitude of LTP (% of baseline) in the different experimental conditions. ***p < 0.001.

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