Fig. 2: PLX3397 reverses excitatory neurotransmission alterations Aβ-mediated. | Translational Psychiatry

Fig. 2: PLX3397 reverses excitatory neurotransmission alterations Aβ-mediated.

From: Switch to phagocytic microglia by CSFR1 inhibition drives amyloid-beta clearance from glutamatergic terminals rescuing LTP in acute hippocampal slices

Fig. 2

A On top, representative traces from different experimental conditions are shown; on the right, histograms show change in PPR in different experimental conditions, vehicle+Aβ1–42 (n = 8), PLX + Aβ1–42 (n = 7), PLX+ Aβscrambled (n = 7). **p < 0.001 Aβ1–42 vs. vehicle; ##p < 0.001 Aβ1–42 vs. PLX + Aβ1–42. B On top, representative traces in different experimental condition are shown. On the right, histograms show AMPA/NMDA ratio in different experimental conditions, vehicle+Aβ1–42 (n = 8), PLX + Aβ1–42 (n = 7), PLX + Aβscrambled (n = 7). **p < 0.001 Aβ1–42 vs. vehicle; ##p < 0.001 Aβ1–42 vs. PLX + Aβ1–42. C On top representative traces from different experimental conditions are shown. The histograms show the effect of Aβ1–42 on amplitude and frequency of sEPSC (as % of baseline) in different experimental conditions, vehicle + Aβ1–42 (n = 5), PLX + Aβ1–42 (n = 6), PLX + Aβscrambled (n = 5) *p < 0.05.

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