Fig. 2: Transcriptomic changes in the DLPFC from donors with AUD. | Translational Psychiatry

Fig. 2: Transcriptomic changes in the DLPFC from donors with AUD.

From: Divergent gene expression patterns in alcohol and opioid use disorders lead to consistent alterations in functional networks within the dorsolateral prefrontal cortex

Fig. 2: Transcriptomic changes in the DLPFC from donors with AUD.The alternative text for this image may have been generated using AI.

A Volcano plot shows DEGs (red) from AUD versus control donors in the DLPFC. The horizontal dashed line represents the FDR significance cut-off (<0.25), and the dashed vertical lines represent a Log2FC cut-off ±0.20 (FC = 1.15). B Heatmap representing gene expression of all 364 DEGs. Samples were clustered using hierarchical cluster analysis by expression similarity. Each column represents a different subject. Top bar plots represent phenotypic data from each subject. Samples from donors with AUD are shown in green, and the control is in grey. AUD samples are clustered into a single distinct group. C PCA shows a large overlap between the AUD and control samples. Ellipses represent a 90% confidence range. D Top GO terms enriched in the AUD group. The size of the circle represents the −log10(P-value), and the odds ratio measures the effect size. E Pathway analysis shows the top 20 canonical pathways enriched in the AUD group. Pathways were clustered based on the extent of overlap among genes.

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