Fig. 5: Genomic and transcriptomic integration. | Translational Psychiatry

Fig. 5: Genomic and transcriptomic integration.

From: Divergent gene expression patterns in alcohol and opioid use disorders lead to consistent alterations in functional networks within the dorsolateral prefrontal cortex

Fig. 5

A Extent of heritability elucidated by AUD and OUD1-DEGs across various traits and neuropsychiatric conditions. B Transcriptome-wide association analysis showing predicted gene expression levels within the DLPFC based on genetic variants associated with PAU and OUD and their overlapping with the set of OUD1-DEGs. Displayed are the genes shared across multiple conditions, accompanied by their predicted and observed gene expression levels. Genes showing upregulation are highlighted in red, while those exhibiting downregulation are depicted in blue.

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