Table 3 Group differences between Toxoplasma gondii (TG) immunoglobulin G (IgG) seropositive (TG+) patients with severe mental illness and healthy controls (HC) in sex, age, education years, handedness (right-handedness vs. left-handedness/ambidexterity), alcohol use disorder identification test (AUDIT) and drug use disorder identification test (DUDIT) scores.

	TG + patients		TG + HC		P-value^b	Correlation with TG
	N^a	Mean (SD) or %	N^a	Mean (SD) or %	P-value^b	±	P-value^c
Sex (% women)	159	42.8	126	42.9	0.988	+	0.296
Age (years)	159	32.2 (11.7)	126	33.3 (8.8)	0.355	-	0.832
Education years	138	12.7 (2.3)	126	14.2 (2.2)	<0.001	-	0.060
Handedness (% right-handedness)	138	87.7	126	91.3	0.344	+	0.854
AUDIT score	116	7 (6.3)	92	5.5 (3.1)	0.023	+	0.787
DUDIT score	124	3.3 (6.8)	95	0.17 (0.63)	<0.001	+	0.778
DOI (years)	156	8.7 (7.7)				+	0.640
PANSS total score	156	54 (14.5)				+	0.068
YMRS score	127	3.7 (4)				+	0.097
IDS-C	108	16.6 (11.1)				+	0.993
On antipsychotics (%)	159	74.2				-	0.208
CPZ (mg/day)	115	320.6 (226.2)				+	0.209
On antidepressants (%)	159	32.7				+	0.167
On antiepileptics (%)	159	21.4				+	0.650
On lithium (%)	159	10.7				-	0.853

For patients, the duration of illness (DOI), Positive and Negative Syndrome Scale (PANSS) score, Young Mania Rating Scale (YMRS) score, Inventory of Depressive Symptoms, clinician rated, score (IDS-C), the percentage of patients on antipsychotics, antidepressants, antiepileptics, and lithium as well as the chlorpromazine equivalent doses (CPZ) among patients on antipsychotics are also shown. P values < 0.05 shown in bold.
^aNumber of participants with data in each variable.
^bChi-square test or t-test (Welch’s t-test in case of unequal variance).
^cPoint-biserial correlations for binary variables; Spearman’s correlations for quantitative variables.

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