Table 4 Group differences between Cytomegalovirus (CMV) immunoglobulin G (IgG) seropositive (TG+) patients with severe mental illness and healthy controls (HC) in sex, age, education years, handedness (right-handedness vs. left-handedness/ambidexterity), alcohol use disorder identification test (AUDIT) and drug use disorder identification test (DUDIT) scores.

	CMV + patients		CMV + HC		P-value^b	Correlation with CMV
	N^a	Mean (SD) or %	N^a	Mean (SD) or %	P-value^b	±	P-value^c
Sex (% women)	447	49.4	296	46.6	0.452	+	0.118
Age (years)	447	32.9 (11.2)	296	33.8 (8.7)	0.221	+	0.167
Education years	404	12.7 (2.8)	296	14.4 (2)	<0.001	+	0.948
Handedness (% right-handedness)	403	90.8	296	90.2	0.783	-	0.696
AUDIT score	318	7.2 (7)	172	5.5 (3.5)	<0.001	-	0.170
DUDIT score	341	3.2 (7.7)	176	0.3 (1.5)	<0.001	+	0.642
DOI (years)	436	9.6 (9.2)				+	0.311
PANSS total score	435	57 (16.8)				-	0.955
YMRS score	378	4.82 (5)				+	0.227
IDS-C	315	18 (11.9)				+	0.764
On antipsychotics (%)	447	73.2				-	0.591
CPZ (mg/day)	322	316.6 (242.2)				+	0.612
On antidepressants (%)	447	33.1				-	0.118
On antiepileptics (%)	447	21.3				+	0.790
On lithium (%)	447	7.4				-	0.403

For patients, the duration of illness (DOI), Positive and Negative Syndrome Scale (PANSS) score, Young Mania Rating Scale (YMRS) score, Inventory of Depressive Symptoms, clinician rated, score (IDS-C), the percentage of patients on antipsychotics, antidepressants, antiepileptics, and lithium as well as the chlorpromazine equivalent doses (CPZ) among patients on antipsychotics are also shown. P values < 0.05 shown in bold.
^aNumber of participants with data in each variable.
^bChi-square test or t-test (Welch’s t-test in case of unequal variance).
^cPoint-biserial correlations for binary variables; Spearman’s correlations for quantitative variables.

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