Table 1 Clinico-demographic and imaging variables in healthy volunteer (HV) and schizophrenia (SCZ) groups.
HV | SCZ | t | Kolmogorov–Smirnov Z | Chi-squared | df | p | |
|---|---|---|---|---|---|---|---|
Age (years) | 29.79 [1.84, 8.03] | 26.52 [1.74, 7.99] | – | 1.01 | – | – | 0.26 |
Male, female (n) | 16, 3 | 17, 4 | – | – | 0.07 | – | 0.79 |
Ethnicity White, Black, Asian, other (n) | 10, 5, 3, 1 | 4, 11, 4, 2 | – | – | 5.21 | – | 0.16 |
Current smoker (n) | 5 | 7 | – | – | 0.23 | – | 0.63 |
Cannabis users within last month (n) | 1 | 2 | – | – | 0.26 | – | 0.61 |
Activity injected (MBq) | 265.42 [5.10, 22.22] | 221.24 [12.84, 58.85] | – | 1.23 | – | – | 0.10 |
Injected mass (μg) | 3.19 [0.24, 1.04] | 3.18 [0.35, 1.59] | – | 0.56 | – | – | 0.91 |
Specific radioactivity (GBq/μmol) | 30.17 [2.76, 12.03] | 25.64 [2.21, 10.11] | – | 0.67 | – | – | 0.77 |
Minimum purity (fraction) | 99.97 [0.03, 0.15] | 100 [0.00, 0.00] | – | 0.17 | – | – | 1.00 |
[11C]UCB-J plasma-free fraction (fp) | 0.24 [0.006, 0.02] | 0.27 [0.007, 0.03] | – | 1.20 | – | – | 0.12 |
Illness duration (years) | – | 2.67 [0.46, 2.11] | – | – | – | – | – |
Drug-free interval (days) | – | 180.42 [27.71, 120.78] | – | – | – | – | – |
PANSS Total score | – | 65.29 [3.29, 15.09] | – | – | – | – | – |
PANSS Positive score | – | 17.05 [1.24, 5.69] | – | – | – | – | – |
PANSS Negative score | – | 17.81 [0.95, 4.33] | – | – | – | – | – |
PANSS General score | – | 30.43 [1.81, 8.32] | – | – | – | – | – |
CS VT | 5.53 [0.14, 0.62] | 6.34 [0.37, 1.69] | – | 0.97 | – | – | 0.30 |
ACC | |||||||
DVR | 4.09 [0.12, 0.52] | 3.66 [0.14, 0.66] | – | 1.44 | – | – | 0.03 |
Glu/Cr | 1.14 [0.02, 0.07] | 1.17 [0.02, 0.10] | – | 1.29 | – | – | 0.07 |
Glx/Cr | 1.34 [0.03, 0.12] | 1.35 [0.04, 0.18] | 0.27 | – | – | 38 | 0.79 |
Left hippocampus | |||||||
DVR | 2.75 [0.09, 0.38] | 2.57 [0.11, 0.49] | – | 0.63 | – | – | 0.83 |
Glu/Cr | 1.01 [0.04, 0.19] | 1.06 [0.03, 0.13] | 0.11 | – | – | 38 | 0.30 |
Glx/Cr | 1.42 [0.07, 0.30] | 1.42 [0.04, 0.19] | 0.05 | – | – | 38 | 0.96 |
