Table 2 PRS Associations.

From: Distinguishing clinical and genetic risk factors for suicidal ideation and behavior in a diverse hospital population

Outcome

PRS

Beta

SE

P

Liability R2%

N Cases

N Controls

Effective N

SB vs. controls

SA

0.178 (0.153)

0.04 (0.053)

9.93 × 10−6* (1.81 × 10−4)**

0.325 (0.240)

1051

42,330

4,079.991

SB vs. controls

SI

0.122

0.053

0.021

0.066

1051

42,330

4,079.991

SI-only vs. controls

SA

0.092

0.044

0.035

0.146

883

42,330

3,446.367

SI-only vs. controls

SI

0.155 (0.141)

0.057 (0.058)

6.82 × 10−3* (0.015)

0.257 (0.207)

883

42,330

3,446.367

SB vs. SI-only

SA

0.089

0.060

0.137

0.160

1051

883

1,918.224

SB vs. SI-only

SI

−0.036

0.075

0.633

0.178

1051

883

1,918.224

  1. Test statistics from logistic regression testing the associations between suicide outcomes and PRS for suicide outcomes. Values in parentheses represent test statistics after controlling for BD, DEP, and SCZ PRS (multi PRS model). Bold indicates significance, * indicates significant associations in the single PRS model, and ** indicates significant associations in the multi PRS model. We used a Bonferroni-corrected p-value threshold of 8.33 × 10−3.
  2. PRS polygenic risk score, SB suicidal behavior, SI suicidal ideation, SA suicide attempt.
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