Table 3 Main effects models for association between the presence of MetS and antidepressant type.

From: Increased odds of metabolic syndrome among adults with depressive symptoms or antidepressant use

MetS (yes/no)

Antidepressant type

OR (95% CI)

p-value

aOR (95% CI)

p-value

SSRIs

1.53 (1.24, 1.88)

<0.001

1.18 (0.92, 1.53)

0.190

SNRIs

1.70 (1.12, 2.57)

0.013

1.24 (0.80, 1.93)

0.331

TCA

3.49 (2.29, 5.32)

<0.001

2.27 (1.31, 3.93)

0.004

Atypical antidepressants

1.44 (1.02, 2.04)

0.040

1.08 (0.73, 1.61)

0.694

More than one type

2.03 (1.46, 2.83)

<0.001

1.19 (0.84, 1.69)

0.317

  1. OR unadjusted odds ratio, aOR adjusted odds ratio, CI confidence interval, the reference level for antidepressant type is “non-user”. Covariates in adjusted models include all 15 pre-selected covariates and depressive symptom severity (total PHQ-9 scores). p-values < 0.05 denote statistical significance.
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