Fig. 1
A Schematic representation of experimental timeline. 3BC 3-bottle choice, ASA alcohol self-administration, PR progressive ratio, Cued Reinst cued reinstatement, MEM memantine, NTX naltrexone, SSA saccharin self-administration. B Effect of Memantine (n = 83) on alcohol self-administration at whole population level. The intermediate and highest dose of Memantine significantly reduced alcohol self-administration. Groups mean ± 95%CI: 0.0 mg/kg, 17.99 ± 1.65; 6 mg/kg, 16.64 ± 2.3; 12.0 mg/kg, 12.27 ± 1.81; 25.0 mg/kg, 6.024 ± 1.445. C Effect of Naltrexone (n = 82) on alcohol self-administration at whole population level. Both doses of Naltrexone significantly reduced alcohol self-administration. Groups mean ± 95%CI: 0.0 mg/kg, 18.87 ± 1.59; 0.3 mg/kg, 13.21 ± 1.61; 1.0 mg/kg, 10.67 ± 1.35. Bars represent the Mean ± 95%CI of number of rewards earned in a 30 min session. Statistical significance: *p < 0.05 and ***p < 0.001 vs vehicle.
