Fig. 3: Effect of Memantine and Naltrexone treatment on saccharin self-administration in clusters based on individual effect of the drugs on ASA. | Translational Psychiatry

Fig. 3: Effect of Memantine and Naltrexone treatment on saccharin self-administration in clusters based on individual effect of the drugs on ASA.

From: Predicting individual treatment response in alcohol use disorders: a reverse translational proof-of-concept study

Fig. 3

A All doses of Memantine reduced saccharin self-administration in MEM1 cluster. Groups mean ± 95%CI: 0.0 mg/kg, 54.18 ± 10.69; 6 mg/kg, 28.17 ± 12.8; 12.0 mg/kg, 17.61 ± 7.22; 25.0 mg/kg, 8.912 ± 3.94. B All doses of Memantine reduced saccharin self-administration in and MEM2 cluster. Groups mean ± 95%CI: 0.0 mg/kg, 54.83 ± 8.6; 6 mg/kg, 37.48 ± 11.74; 12.0 mg/kg, 24.76 ± 9.07; 25.0 mg/kg, 11.17 ± 5.076. C Only by the highest dose of Naltrexone reduced Saccharin self-administration in cluster NTX1. Groups mean ± 95%CI: 0.0 mg/kg, 53.24 ± 9.42; 0.3 mg/kg, 45.93 ± 8.97; 1.0 mg/kg, 36.67 ± 7.1. D Saccharin self-administration was reduced by both Naltrexone doses in cluster NTX2. Groups mean ± 95%CI: 0.0 mg/kg, 70.48 ± 14.11; 0.3 mg/kg, 56.41 ± 11.64; 1.0 mg/kg, 52.07 ± 9.41. Bars represent the Mean ± 95% CI of number of rewards earned in a 30 min session. Statistical significance: **p < 0.01, ***p < 0.001, and ****p < 0.0001 vs vehicle.

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