Fig. 5: Comparison of alcohol drinking, motivation and cued reinstatement between NTX-R (female n = 17. male n = 30) and NTX-NR (female n = 25. male n = 10) cluster. | Translational Psychiatry

Fig. 5: Comparison of alcohol drinking, motivation and cued reinstatement between NTX-R (female n = 17. male n = 30) and NTX-NR (female n = 25. male n = 10) cluster.

From: Predicting individual treatment response in alcohol use disorders: a reverse translational proof-of-concept study

Fig. 5

A Factor analysis using principal component extraction followed by varimax normalized rotation of alcohol drinking in three-bottle choice test (3BC), break point in progressive ratio test (PR) and cued reinstatement test (Cue). B Male and female NTX-R and NTX-NR rats showed similar level of daily alcohol intake at both 5% and 10% alcohol concentration in three-bottle choice test. Groups mean ± 95%CI: Female alcohol 5%, NTX-R 2.098 ± 0.947, NTX-NR 1.661 ± 0.603; Female alcohol 10%, NTX-R 1.25 ± 0.451, NTX-NR 1.461 ± 0.561; Male alcohol 5%, NTX-R 0.988 ± 0.277, NTX-NR 0.84 ± 0.495; Male alcohol 10%, NTX-R 0.842 ± 0.235, NTX-NR 1.321 ± 1.162. C Male and female NTX-R and NTX-NR rats showed similar level of motivation expressed by the break point reached under PR contingency over three consecutive PR sessions. Groups mean ± 95%CI: Female session1, NTX-R 8.353 ± 2.596, NTX-NR 8.6 ± 1.39; Female session2, NTX-R 7.294 ± 2.403, NTX-NR 6.04 ± 1.127; Female session3, NTX-R 6.118 ± 2.418, NTX-NR 4.96 ± 0.964; Male session1, NTX-R 8.667 ± 1.722, NTX-NR 6.9 ± 2.79; Male session2, NTX-R 7.7 ± 1.157, NTX-NR 6.8 ± 1.679; Male session3, NTX-R 7.2 ± 1.191, NTX-NR 7.0 ± 1.686. D Alcohol olfactory, taste and visual cues reinstated alcohol seeking in both NTX-R and NTX-NR female rats and in NTX-R male rats but not in NTX-NR male rats. Groups mean ± 95%CI: Female Ext, NTX-R 8.176 ± 2.392, NTX-NR 8.72 ± 2.163; Female Cue, NTX-R 17.47 ± 5.7, NTX-NR 19.36 ± 3.1; Male Ext, NTX-R 7.433 ± 2.375, NTX-NR 12.1 ± 12.86; Male Cue, NTX-R 23.43 ± 6.685, NTX-NR 13.6 ± 6.025. Bars represent the Mean ± 95%CI of respectively B) average 24 h alcohol intake, C) break point, and D) number active lever presses produced in a 30 min session on the last day of extinction (Ext) and on cued reinstatement test (Cue). Statistical significance: *p < 0.05, ***p < 0.001, and ****p < 0.0001 vs Ext same group.

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