Table 2 Group differences in hurst exponent (H) per component, in the exploratory dataset, computed using ANCOVA with age and sex as covariates.
From: Using the excitation/inhibition ratio to optimize the classification of autism and schizophrenia
Adjusted H mean (SE) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
IC no. [X Y Z] MNI coordinates | TD | AT | SZ | F (2, 1069) | p | pfdr | ηp2 | Post hoc | |
SUBCORTICAL DOMAIN | |||||||||
1 | Caudate 1 [6.5 10.5 5.5] | 0.57 (0.01) | 0.59 (0.02) | 0.49 (0.01) | 16.34 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ *** |
2 | Subthalamus/hypothalamus [−2.5 −13.5 −1.5] | 0.77 (0.01) | 0.78 (0.02) | 0.68 (0.01) | 15.33 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ *** |
3 | Putamen [−26.5 1.5 −0.5] | 0.88 (0.01) | 0.89 (0.02) | 0.81 (0.01) | 11.45 | <0.001 | 0 | 0.02 | AT > SZ ** TD > SZ *** |
4 | Caudate 2 [21.5 10.5 −3.5] | 0.57 (0.01) | 0.58 (0.02) | 0.5 (0.01) | 13.8 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ *** |
5 | Thalamus [−12.5 −18.5 11.5] | 0.91 (0.01) | 0.89 (0.02) | 0.81 (0.01) | 13.96 | <0.001 | 0 | 0.03 | AT > SZ ** TD > SZ *** |
AUDITORY DOMAIN | |||||||||
6 | Superior temporal gyrus [62.5 −22.5 7.5] | 0.55 (0.01) | 0.56 (0.02) | 0.47 (0.01) | 16.5 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ *** |
7 | Middle temporal gyrus [−42.5 −6.5 10.5] | 0.7 (0.01) | 0.71 (0.02) | 0.63 (0.01) | 15.3 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ *** |
SENSORIMOTOR DOMAIN | |||||||||
8 | Postcentral gyrus 1 [56.5 −4.5 28.5] | 0.91 (0.01) | 0.87 (0.02) | 0.82 (0.01) | 11.39 | <0.001 | 0 | 0.02 | TD > SZ *** |
9 | Left postcentral gyrus [−38.5 −22.5 56.5] | 0.83 (0.01) | 0.82 (0.02) | 0.74 (0.01) | 15.1 | <0.001 | 0 | 0.03 | AT > SZ ** TD > SZ *** |
10 | Paracentral lobule 1 [0.5 −22.5 65.5] | 0.62 (0.01) | 0.7 (0.02) | 0.54 (0.01) | 37.2 | <0.001 | 0 | 0.07 | AT > SZ *** TD > SZ *** TD < AT *** |
11 | Right postcentral gyrus [38.5 −19.5 55.5] | 0.84 (0.01) | 0.81 (0.02) | 0.76 (0.01) | 12.71 | <0.001 | 0 | 0.02 | AT > SZ * TD > SZ *** |
12 | Superior parietal lobule [−18.5 −43.5 65.5] | 0.94 (0.01) | 0.91 (0.02) | 0.86 (0.01) | 21.81 | <0.001 | 0 | 0.02 | AT > SZ * TD > SZ *** |
13 | Paracentral lobule 2 [−18.5 −9.5 56.5] | 0.62 (0.01) | 0.65 (0.02) | 0.52 (0.01) | 30.66 | <0.001 | 0 | 0.05 | AT > SZ *** TD > SZ *** |
14 | Precentral gyrus [−42.5 −7.5 46.5] | 0.53 (0.01) | 0.57 (0.02) | 0.46 (0.01) | 20.65 | <0.001 | 0 | 0.04 | AT > SZ *** TD > SZ *** |
15 | Superior parietal lobule [20.5 −63.5 58.5] | 0.94 (0.01) | 0.92 (0.02) | 0.83 (0.01) | 19.98 | <0.001 | 0 | 0.04 | AT > SZ *** TD > SZ *** |
16 | Postcentral gyrus 2 [−47.5 −27.5 43.5] | 0.9 (0.01) | 0.88 (0.02) | 0.8 (0.01) | 16.37 | <0.001 | 0 | 0.03 | AT > SZ ** TD > SZ *** |
VISUAL DOMAIN | |||||||||
17 | Calcarine gyrus [−12.5 −66.5 8.5] | 0.68 (0.01) | 0.74 (0.02) | 0.61 (0.01) | 26.43 | <0.001 | 0 | 0.05 | AT > SZ *** TD > SZ *** TD < AT ** |
18 | Middle occipital gyrus [−23.5 −93.5 −0.5] | 0.75 (0.01) | 0.78 (0.02) | 0.63 (0.01) | 32.1 | <0.001 | 0 | 0.06 | AT > SZ *** TD > SZ *** |
19 | Middle temporal gyrus [48.5 −60.5 10.5] | 0.57 (0.01) | 0.63 (0.02) | 0.51 (0.01) | 17.72 | <0.001 | 0 | 0.03 | AT > SZ ** TD > SZ *** TD < AT *** |
20 | Cuneus [15.5 −91.5 22.5] | 0.92 (0.01) | 0.89 (0.02) | 0.84 (0.01) | 12.77 | <0.001 | 0 | 0.02 | AT > SZ * TD > SZ *** |
21 | Right middle occipital gyrus [38.5 −73.5 6.5] | 0.81 (0.01) | 0.81 (0.02) | 0.73 (0.01) | 18.59 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ *** |
22 | Fusiform gyrus [29.5 −42.5 −12.5] | 0.59 (0.01) | 0.66 (0.02) | 0.53 (0.01) | 30.33 | <0.001 | 0 | 0.05 | AT > SZ *** TD > SZ *** TD < AT *** |
23 | Inferior occipital gyrus [−36.5 −76.5 −4.5] | 0.81 (0.01) | 0.85 (0.02) | 0.74 (0.01) | 21.21 | <0.001 | 0 | 0.04 | AT > SZ * TD > SZ *** TD < AT *** |
24 | Lingual gyrus [−8.5 −81.5 −4.5] | 0.54 (0.01) | 0.53 (0.02) | 0.49 (0.01) | 6.01 | <0.00 | 0 | 0.01 | TD > SZ *** |
25 | Middle temporal gyrus [−44.5 −57.5 −7.5] | 0.68 (0.01) | 0.72 (0.01) | 0.64 (0.01) | 10.61 | <0.001 | 0 | 0.02 | AT > SZ *** TD > SZ ** |
COGNITIVE CONTROL DOMAIN | |||||||||
26 | Inferior parietal lobule 1 [45.5 −61.5 43.5] | 0.55 (0.01) | 0.57 (0.02) | 0.48 (0.01) | 15.68 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ *** |
27 | Insula [−30.5 22.5 −3.5] | 0.78 (0.01) | 0.8 (0.02) | 0.68 (0.01) | 24.6 | <0.001 | 0 | 0.04 | AT > SZ *** TD > SZ *** |
28 | Superior medial frontal gyrus [−0.5 50.5 29.5] | 0.66 (0.01) | 0.73 (0.02) | 0.61 (0.01) | 15.35 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ ** TD < AT ** |
29 | Inferior frontal gyrus [−48.5 34.5 −0.5] | 0.59 (0.01) | 0.64 (0.01) | 0.54 (0.01) | 16.97 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ *** TD < AT * |
30 | Right inferior frontal gyrus [53.5 22.5 13.5] | 0.64 (0.01) | 0.67 (0.02) | 0.54 (0.01) | 32.12 | <0.001 | 0 | 0.06 | AT > SZ *** TD > SZ *** |
31 | Middle frontal gyrus [−41.5 19.5 26.5] | 0.62 (0.01) | 0.67 (0.01) | 0.54 (0.01) | 31.87 | <0.001 | 0 | 0.06 | AT > SZ *** TD > SZ *** TD < AT ** |
32 | Inferior parietal lobule 2 [−53.5 −49.5 43.5] | 0.91 (0.01) | 0.92 (0.02) | 0.85 (0.01) | 12.5 | <0.001 | 0 | 0.02 | AT > SZ *** TD > SZ *** |
33 | Left inferior parietal lobule [44.5 −34.5 46.5] | 0.79 (0.01) | 0.82 (0.01) | 0.73 (0.01) | 16.95 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ *** |
34 | Supplementary motor area [−6.5 13.5 64.5] | 0.55 (0.01) | 0.55 (0.02) | 0.49 (0.01) | 9.14 | <0.001 | 0 | 0.02 | AT > SZ ** TD > SZ *** |
35 | Superior frontal gyrus [−24.5 26.5 49.5] | 0.6 (0.01) | 0.69 (0.02) | 0.52 (0.01) | 42.94 | <0.001 | 0 | 0.07 | AT > SZ *** TD > SZ *** TD < AT *** |
36 | Middle frontal gyrus 1 [30.5 41.5 28.5] | 0.6 (0.01) | 0.62 (0.02) | 0.52 (0.01) | 19.83 | <0.001 | 0 | 0.04 | AT > SZ *** TD > SZ *** |
37 | Hippocampus 1 [23.5 −9.5 −16.5] | 0.62 (0.01) | 0.66 (0.01) | 0.57 (0.01) | 17.47 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ *** |
38 | Left inferior parietal lobule [45.5 −61.5 43.5] | 0.76 (0.01) | 0.8 (0.02) | 0.72 (0.01) | 9.63 | <0.001 | 0 | 0.02 | AT > SZ *** TD > SZ * TD < AT * |
39 | Middle cingulate cortex [−15.5 20.5 37.5] | 0.83 (0.01) | 0.85 (0.02) | 0.75 (0.01) | 18.12 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ *** |
40 | Inferior frontal gyrus [39.5 44.5 −0.5] | 0.89 (0.01) | 0.91 (0.02) | 0.83 (0.01) | 12.78 | <0.001 | 0 | 0.02 | AT > SZ *** TD > SZ *** |
41 | Middle frontal gyrus 2 [−26.5 47.5 5.5] | 0.67 (0.01) | 0.7 (0.02) | 0.6 (0.01) | 19.1 | <0.001 | 0 | 0.03 | AT > SZ *** TD > SZ *** |
42 | Hippocampus 2 [−24.5 −36.5 1.5] | 0.55 (0.01) | 0.55 (0.02) | 0.48 (0.01) | 10.69 | <0.001 | 0 | 0.02 | AT > SZ ** TD > SZ *** |
DEFAULT MODE DOMAIN | |||||||||
43 | Precuneus 1 [−8.5 −66.5 35.5] | 0.89 (0.01) | 0.94 (0.02) | 0.81 (0.01) | 23.02 | <0.001 | 0 | 0.04 | AT > SZ *** TD > SZ *** |
44 | Precuneus 2 [−12.5 −54.5 14.5] | 0.68 (0.01) | 0.76 (0.02) | 0.6 (0.01) | 33.29 | <0.001 | 0 | 0.06 | AT > SZ *** TD > SZ *** TD < AT *** |
45 | Anterior cingulate cortex 1 [−2.5 35.5 2.5] | 0.69 (0.01) | 0.61 (0.02) | 0.57 (0.01) | 25.34 | <0.001 | 0 | 0.05 | TD > SZ * TD > AT * |
46 | Posterior cingulate cortex 1 [−5.5 −28.5 26.5] | 0.9 (0.01) | 0.89 (0.02) | 0.84 (0.01) | 9.29 | <0.001 | 0 | 0.02 | AT > SZ * TD > SZ *** |
47 | Anterior cingulate cortex 2 [−9.5 46.5 −10.5] | 0.57 (0.01) | 0.68 (0.02) | 0.5 (0.01) | 48.15 | <0.001 | 0 | 0.08 | AT > SZ *** TD > SZ *** TD < AT *** |
48 | Precuneus 3 [−0.5 −48.5 49.5] | 0.65 (0.01) | 0.63 (0.02) | 0.6 (0.01) | 6.81 | <0.00 | 0 | 0.01 | TD > SZ *** |
49 | Posterior cingulate cortex 2 [−2.5 54.5 31.5] | 0.74 (0.01) | 0.74 (0.02) | 0.68 (0.01) | 10.98 | <0.001 | 0 | 0.02 | AT > SZ ** TD > SZ *** |
CEREBELLAR DOMAIN | |||||||||
50 | Cerebellum 1 [−30.5 −54.5 −42.5] | 0.64 (0.01) | 0.69 (0.02) | 0.56 (0.01) | 27.74 | <0.001 | 0 | 0.05 | AT > SZ *** TD > SZ *** TD < AT * |
51 | Cerebellum 2 [−32.5 −79.5 −37.5] | 0.83 (0.01) | 0.85 (0.02) | 0.75 (0.01) | 19.32 | <0.001 | 0 | 0.04 | AT > SZ *** TD > SZ *** |
52 | Cerebellum 3 [20.5 −48.5 −40.5] | 0.64 (0.01) | 0.61 (0.02) | 0.56 (0.01) | 13.51 | <0.001 | 0 | 0.03 | TD > SZ *** |
53 | Cerebellum 4 [30.5 −63.5 −40.5] | 0.68 (0.01) | 0.63 (0.02) | 0.59 (0.01) | 18.59 | <0.001 | 0 | 0.03 | TD > SZ *** TD > AT ** |
