Fig. 1: Flow chart of this study and identification in CYP2D6 genotype. | Translational Psychiatry

Fig. 1: Flow chart of this study and identification in CYP2D6 genotype.

From: Advancing paroxetine treatment in depression: predicting remission and plasma concentration, and validating and updating therapeutic reference ranges

Fig. 1

a Flow chart of this 8-week study of paroxetine monotherapy and prediction model development. b CYP2D6 copy number detection and SNPs genotyping. For example, if a patient has a CYP2D6 gene copy number of 2N, a genotype of A.DEL at rs5030655 (indicating a deletion variant), and a genotype of GT at rs5030867, the patient is considered to carry one *6 and one *7 allele, classifying their CYP2D6 genotype as *6/*7. Css steady-state concentration, MDD major depressive disorder, ROC analysis, receiver operating characteristic curve analysis, SNP single nucleotide polymorphism.

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