Fig. 2: Diffusion tensor imaging (DTI) reveals decreased fractional anisotropy (FA) in SCZ and allows patient stratification. | Translational Psychiatry

Fig. 2: Diffusion tensor imaging (DTI) reveals decreased fractional anisotropy (FA) in SCZ and allows patient stratification.

From: iPSC-modelling reveals genetic associations and morphological alterations of oligodendrocytes in schizophrenia

Fig. 2

(A) Investigation of the FA of the whole brain white matter skeleton with tract-based spatial statistics (TBSS) based on DTI in patients with SCZ (N = 58) compared to unaffected healthy controls (Ctrl; N = 54). Investigated areas are displayed in green on the left, areas with significant lower FA values in SCZ compared to Ctrl are depicted in a red-yellow scale from the second to fourth brain images. X, y, and z indicate the brain map coordinates. (B) Violin plots illustrate quantification of whole brain FA based on TBSS in SCZ patients and Ctrl. FA values of the patient and Ctrl representatives that are further investigated with iOL are individually illustrated on the right. Data = Mean ± SD. T-test: ***, p < 0.001; ****, p < 0.0001.

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