Fig. 5: Image analysis reveals morphological alterations of MBP+ oligodendrocytes in SCZ. | Translational Psychiatry

Fig. 5: Image analysis reveals morphological alterations of MBP+ oligodendrocytes in SCZ.

From: iPSC-modelling reveals genetic associations and morphological alterations of oligodendrocytes in schizophrenia

Fig. 5

(A) Representative original (top), processed (middle), and ridge detection (bottom) images of MBP+ iOLs from SCZ patients and Ctrl. Boxplots illustrate the (B) percentage of MBP+ iOLs (Ctrl, N = 7, n = 9–11 fields of view / cell line, vs. SCZ, N = 7, n = 9–11 fields of view / cell line) and the (C) quantification of average cell size (Ctrl, N = 7, n = 8–11 fields of view / cell line, vs. SCZ, N = 7, n = 8–11 fields of view / cell line), and the morphological quantification with ridge detection of (D) average branch length and (E) average junction number (Ctrl, N = 7, n = 8–10 fields of view / cell line, vs. SCZ, N = 7, n = 8–10 fields of view / cell line). Data are based on biological independent hiPSC lines from 7 patients with SCZ and 7 Ctrl. Scale bar indicates 50 μm, Data = Mean ± SD. Mixed-effects ANOVA with group identity (SCZ-Ctrl) as the between-group factor: *, p < 0.05.

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