Fig. 4: Altered brain-behavior relationships in mice with SSCE exposure. | Translational Psychiatry

Fig. 4: Altered brain-behavior relationships in mice with SSCE exposure.

From: Multi-connectomics underpin emotional dysfunction in mouse exposed to simulated space composite environment

Fig. 4

a Spearman’s correlation patterns between network-wise functional connectivity and three behavioral measures: the percentage of time in the open arms in the EPM: EPM-percentage (left), Stillness duration in the TST: TST-still (middle), sniffing time in the social test: Social-sniff (right). Note that, the upper and lower triangles of the matrix respectively represent the CON and SSCE groups after 4 weeks of modeling. Asterisks indicate correlations that passed the significance threshold of 0.05. b Contrasting network-wise brain-behavior relationships between the SSCE and the CON groups in terms of EPM and Social tests. c Circular heatmaps summarizing spearman’s correlations between PFC-specific ROI-wise FC and the three behavioral measures. The inner and outer arcs respectively represent the CON and SSCE groups after 4 weeks of modeling. The blocks outlined in black indicate correlations that passed the significance threshold of 0.05. d PFC-specific brain-behavior relationships in the SSCE group are the opposite of those in the CON group in terms of EPM and Social tests.

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