Fig. 1: Effects of NMDA excitotoxic lesions on striatal subregions (the dorsolateral striatum (DLS), dorsomedial striatum (DMS), and nucleus accumbens (NA)) in the mouse version of two-choice probabilistic task (2C task) of Experiment 1.
A Illustration depicting the trial structure of the mouse version of the 2C task utilized in this study. B Mean ± SEM of accumulated trials for the lesion and sham groups across three subregions of the striatum during the testing phase of the 2C task. C Mean ± SEM percentage of different choice strategies (win-stay, win-shift, lose-stay, and lose-shift) for the lesion and sham groups within the three striatal subregions. D Group-level distributions of model parameters derived from reward-no-reward model-based analysis in Experiment 1. Notably, mice with DMS lesions exhibited significantly lower reward learning rate (αrew) and no-reward learning rate (αnor) but higher choice consistency (β) compared to their sham controls (* p < 0.05).
