Fig. 3: Effects of chemogenetic inhibition of the dorsomedial striatum (DMS) on decision-making behavior in Akt1 heterozygous (HET) mice in Experiment 4.
A Average powers in the DMS between HET and WT mice during habituation in the testing chamber. B Heatmap showing overall viral spread within the dorsomedial striatum (DMS), averaging ~73%, along with representative images from WT, HET-Control, and HET-CNO (clozapine N-oxide) groups. C Mean ± SEM travel distance among the three groups before (left panel) and after (right panel) brain surgery, showing no significant differences. D Mean ± SEM accumulated trials for the three groups in the two-choice probabilistic task (Experiment 4). A significant enhancement of accumulated trials was observed in the HET-CNO group compared to the HET-control group. E Mean ± SEM of the ratio of different choice strategies (win-stay, win-shift, lose-stay, and lose-shift) for the three groups. Analysis revealed an increased lose-stay strategy in the HET-CNO group compared to the HET-control group. F Group-level distributions of model parameters (reward learning rate (αrew), no-reward learning rate (αnor), and choice consistency (ß)) derived from reward-no-reward model-based analysis. The HET-CNO group exhibited a decreased αnor and an increased ß compared to the HET-control group. *p < 0.05.
