Fig. 5: Selective lesion of parvalbumin (PV) interneurons in the dorsomedial striatum (DMS) of DTA-treated PV-Cre mice resulted in a reduction of PV positive cells and diminished behavioral performance in the two-choice probabilistic task in Experiment 6.
A Representative images illustrating PV-positive cells in the DMS of DTA-treated PV-Cre mice (PV-DTA group) and PV-sham controls (PV-Sham group). A significant reduction of PV-positive cells was observed in the PV-DTA group. B Mean ± SEM travel distance before (left panel) and after (right panel) selective lesion of PV interneurons in the DMS, showing no significant group difference. C Mean ± SEM accumulated trials in the two-choice probabilistic task, revealing decreased accumulated trials in the PV-DTA group compared to the PV-Sham group. D Mean ± SEM of the ratio of different choice strategies (win-stay, win-shift, lose-stay, and lose-shift) for the PV-DTA group compared to the PV-Sham group. Analysis revealed a decreased lose-shift strategy in the PV-DTA group compared to the PV-Sham group. E Group-level distributions of model parameters (reward learning rate (αrew), no-reward learning rate (αnor), and choice consistency (ß)) derived from reward-no-reward model-based analysis. Mice in the PV-DTA group exhibited higher αrew, higher αnor, and lower ß compared to the WT Sham group. *p < 0.05.
