Fig. 3: Deep brain stimulation of medial forebrain bundle evoke noradrenalin release in nucleus accumbens (NAc). | Translational Psychiatry

Fig. 3: Deep brain stimulation of medial forebrain bundle evoke noradrenalin release in nucleus accumbens (NAc).

From: Deep brain stimulation of medial forebrain bundle modulates noradrenergic activity and feedforward inhibition in rodent model of depression

Fig. 3

A-F NA release 5 s prior to DBS, 5 s during DBS, and 45 s post-DBS under different conditions and across the experimental groups; (A´-F´) Pre-DBS vs DBS release under different conditions and across the experimental groups. (A, A´) NA release in NAc at 30 Hz 100 μs. (B, B´)130 Hz 100 μs. (C, C´) 30 Hz 250 μs. (D, D´) 130 Hz 250 μs. (E, E´) 30 Hz 350 μs. (F, F´) 130 Hz 350 μs; animal strains versus stimulation condition (pre DBS, −5 - 0 and during DBS, 0 - 5). G The initial time of signal activation under diverse stimulation parameters at PFC in SD and FSL rats. H The initial time of signal activation under diverse stimulation parameters at NAc in SD and FSL rats. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns, non-significant. Error bars: SEM.

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