Fig. 5: Activation of noradrenergic cell group by unilateral medial forebrain bundle stimulation. | Translational Psychiatry

Fig. 5: Activation of noradrenergic cell group by unilateral medial forebrain bundle stimulation.

From: Deep brain stimulation of medial forebrain bundle modulates noradrenergic activity and feedforward inhibition in rodent model of depression

Fig. 5

A Immunohistochemical analysis of A1 noradrenergic (NA) cell groups without (sham) and with medial forebrain bundle stimulation (stimulated) the AF488 showed in yellow, AF568 showed in magenta. B Overall density of A1 NA neurons in Sprague Dawley (SD, n = 10) and Flinders Sensitive Line rats (FSL, n = 14). C A1 NA neurons activation in SD rats and FSL rats after 20 times 5 s medial forebrain bundle stimulation compared with unstimulated sham animals. D Immunohistochemical analysis of A2 NA cell groups from sham and stimulated animals. E Overall density of A2 noradrenergic neurons in SD (n = 10) and FSL (n = 13) rats. F A2 NA neurons activation in SD rats and FSL rats after 20 times 5 s medial forebrain bundle stimulation compared with unstimulated sham animals. G Immunohistochemical analysis of A6 NA cell groups from sham and stimulated. H Overall density of A6 noradrenergic neurons in SD (n = 12) and FSL (n = 14) rats. (I) A6 NA neurons activation in SD rats and FSL rats after 20 times 5 s medial forebrain bundle stimulation compared with unstimulated sham animals. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns, non-significant. Error bars: SEM.

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