Fig. 6: Activation of parvalbumin (PV) interneuron and overall c-Fos expression by unilateral mfb DBS in prefrontal cortex (PFC) and nucleus accumbens (NAc). | Translational Psychiatry

Fig. 6: Activation of parvalbumin (PV) interneuron and overall c-Fos expression by unilateral mfb DBS in prefrontal cortex (PFC) and nucleus accumbens (NAc).

From: Deep brain stimulation of medial forebrain bundle modulates noradrenergic activity and feedforward inhibition in rodent model of depression

Fig. 6

A Activated parvalbumin interneuron in PFC from representative animal, AF568 showed in magenta, AF405 showed in cyan. B The density of active PV interneurons with and without DBS at PFC in SD rats and FSL rats, two-way ANOVA. C The density of c-Fos positive neurons at PFC in SD rats and FSL rats, two-way ANOVA. D Activated parvalbumin interneurons in NAc from representative animal, AF568 showed in magenta, AF405 showed in cyan. E The density of active PV interneurons with and without DBS at NAc in SD rats and FSL rats. F The density of c-Fos positive neuron at NAc in SD rats and FSL rats. P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns, non-significant. Error bars: SEM.

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