Fig. 4: Extent of overlap between cognitive biomarkers and biomarkers predictive of response in terms of negative and positive symptoms.

A Information of Table 2 and Supplementary Table S1 (for Trials 1 and 2 respectively) are depicted in blue, with cortical location on the X-axis and calculated EEG metric on the Y-axis. The predictive “strength” (that is, the quantitative correlation between the metric and improvement in cognitive outcome) is indicated by the size of the circle, as shown in the legend. Similarly, biomarkers for response in terms of negative symptom improvement (From Supplementary Table S3) are shown in red. Areas of overlap are shown in shades of purple. B Response pattern for cognitive responders is again depicted in blue. Biomarkers for response in terms of positive symptoms (from Supplementary Table S2) are shown in green. Note the lower degree of overlap, as compared with (A) above. X-axis abbreviations: Fp2, right frontal pole; F8, right prefrontal; T4, right temporal; Or, right temporo-occipital (electrodes T6, P4, and O2); C, central (electrodes, C3, Cz, C4); Ol, left temporo-occipital (electrodes T5, P3, and O1); T3, (left temporal); F7, left prefrontal, Fz, frontal (electrodes F3, Fz, F4). EEG metrics: ratio, β/γ; alpha, 5–14 Hz; lo beta, 14–24 Hz; hi beta, 24–30 Hz; lo gamma, 30–39 Hz; high gamma, 39–50 Hz, PLE, power law exponent.