Fig. 1: Metagenomic sequencing revealed significant differences in the diversity and composition of the gut microbiota in mice receiving fecal microbiota transplantation (FMT) from healthy controls and women with prenatal depression. | Translational Psychiatry

Fig. 1: Metagenomic sequencing revealed significant differences in the diversity and composition of the gut microbiota in mice receiving fecal microbiota transplantation (FMT) from healthy controls and women with prenatal depression.

From: Prenatal depression-associated gut microbiota induces depressive-like behaviors and hippocampal neuroinflammation in germ-free mice

Fig. 1

A FMT experimental design. FMT experiments as well as feeding without any intervention for three weeks were performed in sterile isolators. B The α-diversity of microbiota of two groups using alpha diversity measures Ace, Chao, Sobs and Shannon. C Principal coordinate analysis (PCoA) of bray_curtis distances showed significant difference in β-diversity between two groups. D At the phylum level, the composition and statistical tests of the gut microbiota from two groups. E At the genus levels, the composition and linear discriminant analysis (LDA score > 4) of the gut microbiota in two groups. F Kyoto Encyclopedia of Genes and Genomes (KEGG) functional pathways of gut microbiota between two groups. HC-FMT, mice receiving FMT from women with healthy control (n = 7); PD-FMT, mice receiving FMT from women with prenatal depression (n = 7); data are shown as mean ± SEM; ****, p < 0.0001; differences are assessed by Student’s t-test.

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