Table 1 Functional observational battery assessing the effects of a subcutaneous PMP1 injection in WT and AS mice.
Pre-treatment/30 min post-treatment | ||||||||
|---|---|---|---|---|---|---|---|---|
WT Veh (n = 8) | WT PMP1 (n = 9) | AS Veh (n = 8) | AS PMP1 (n = 7) | |||||
Pre | Post | Pre | Post | Pre | Post | Pre | Post | |
Physical Characteristics | ||||||||
Weight (males) | 25.6±0.6 | 25.0±0.7 | 23.1±3.0 | 23.4±2.5 | 26.0±3.4 | 26.0±3.2 | 28.5±0.7 | 28.5±0.7 |
Weight (females) | 19.3±1.2 | 18.3±0.6 | 20.5±3.5 | 17.5±0.7 | 17.3±2.1 | 18.3±0.6 | 22.2±3.3 | 22.8±1.3 |
Temp | 35.3±0.3 | 35.2±0.3 | 35.0±0.1 | 35.5±0.6 | 35.5±0.2 | 35.3±0.3 | 35.3±0.3 | 35.3±0.2 |
Whiskers | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Bald patch | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Palpebral closure? | 12.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Exothalmos | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
General Behavior - Recorded 1 min in novel empty cage | ||||||||
Sniffing | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Licking | 0 | 0 | 0 | 11.1 | 0 | 0 | 0 | 0 |
Rearing | 100 | 100 | 100 | 100 | 87.5 | 100 | 100 | 100 |
Wild run | 25 | 0 | 11.1 | 11.1 | 25 | 25 | 14.3 | 0 |
Freezing | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Jumping | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Defecation | 25 | 37.5 | 33.3 | 44.4 | 25 | 12.5 | 42.9 | 14.3 |
Urination | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Sensorimotor Reflexes (% of subjects showing normal response) | ||||||||
Righting | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Whiskers | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Eye-blink | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
Ear-twitch | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 |
