Fig. 1: Psilocin effects in medial prefrontal cortex and on layer 5 pyramidal neurons from C57B6/J mice. | Translational Psychiatry

Fig. 1: Psilocin effects in medial prefrontal cortex and on layer 5 pyramidal neurons from C57B6/J mice.

From: Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation

Fig. 1: Psilocin effects in medial prefrontal cortex and on layer 5 pyramidal neurons from C57B6/J mice.The alternative text for this image may have been generated using AI.

A A representative 3D plot of the three selected anatomical regions within the prefrontal cortex: prelimbic (PrL), infralimbic (IL), and anterior cingulate cortex (ACC). B The fMRI signal normalized to the baseline (Error bars represent the standard error) in experiment and control groups. C Averaged fMRI signal changes in PrL, ACC, and IL during the psilocin period in the experimental group and the vehicle period in the control group (F-value = 8.10, p < 0.001). PrL exhibited a trend toward higher fMRI activity compared to IL (β = 2.36, #p = 0.059). Additionally, fMRI responses in ACC and PrL were significantly elevated in the experimental group relative to the control group (ACC: β = 3.13, ***p < 0.005; PrL: β = 2.43, ***p < 0.005). D Representative PFC Layer 5 pyramidal neuron location within slice. Representative recordings of neuronal firing after psilocin (10 µM) showing increase (E), decrease (F), and no change (G). H Graphical depiction of differential neuronal responses to psilocin (10 µM). (I) Averaged psilocin effects on firing in L5P (mean ± SEM, n = 19). J Membrane characteristics of layer V pyramidal neurons (mean ± SEM).

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