Fig. 4: The role of 5-HT2A receptors in the effects of psilocin and NBOH-2C-CN on 5-HT2A neurons. | Translational Psychiatry

Fig. 4: The role of 5-HT2A receptors in the effects of psilocin and NBOH-2C-CN on 5-HT2A neurons.

From: Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation

Fig. 4: The role of 5-HT2A receptors in the effects of psilocin and NBOH-2C-CN on 5-HT2A neurons.The alternative text for this image may have been generated using AI.

A Representative recording of 5-HT2A neuron firing after M100907 (200 nM) and psilocin (10 µM). B Averaged M100907 effects on firing in 5-HT2A neurons (mean ± SEM, n = 10 cells/N = 6 mice). C Normalized M100907 effects on firing in 5-HT2A neurons (mean ± SEM, n = 10 cells/N = 6mice; one sample t-test **p < 0.01). D Averaged M100907 + psilocin effects on firing in 5-HT2A neurons (mean ± SEM, n = 10 cells/N = 6 mice). E Normalized M100907 + psilocin effects on firing in 5-HT2A neurons (mean ± SEM, n = 10 cells/N = 6 mice). F Representative recording of 5-HT2A neuron firing after M100907 (200 nM) and NBOH-2C-CN (200 nM). G Averaged M100907 effects on firing in 5-HT2A neurons (mean ± SEM, n = 9 cell/N = 5 mice; paired t-test *p < 0.05). H Normalized M100907 effects on firing in 5-HT2A neurons (mean ± SEM, n = 9 cells/N = 5 mice; one sample t-test *p < 0.01). I Averaged M100907 + NBOH-2C-CN effects on firing in 5-HT2A neurons (mean ± SEM, n = 11 cells/N=5mice). J Normalized M100907 + NBOH-2C-CN effects on firing in 5-HT2A neurons (mean ± SEM, n = 10/N = 5 mice).

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