Fig. 5: The role of 5-HT2C receptors in the effects of psilocin and NBOH-2C-CN on 5-HT2A neurons. | Translational Psychiatry

Fig. 5: The role of 5-HT2C receptors in the effects of psilocin and NBOH-2C-CN on 5-HT2A neurons.

From: Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation

Fig. 5

A Representative recording of 5-HT2A neuron firing after RS102221 (5 µM) and psilocin (10 µM). B Averaged RS102221 effects on firing in 5-HT2A neurons (mean ± SEM, n = 11 cells/N = 6 mice; paired t-test **p < 0.005). C Normalized RS102221 effects on firing in 5-HT2A neurons (mean ± SEM, n = 11 cells/N = 6 mice; one sample t-test ****p < 0.0001). D Averaged RS102221 + psilocin effects on firing in 5-HT2A neurons (mean ± SEM, n = 11 cells/N = 6 mice; paired t-test *p < 0.05). E Normalized RS102221 + psilocin effects on firing in 5-HT2A neurons (mean ± SEM, n = 10 cells/N = 6 mice ; one sample t-test *p < 0.05). F Representative recording of 5-HT2A neuron firing after RS102221 (5 µM) and NBOH-2C-CN (200 nM). G Averaged RS102221 effects on firing in 5-HT2A neurons (mean ± SEM, n = 9 cells/N = 5 mice; paired t-test **p < 0.01). H Normalized RS102221 effects on firing in 5-HT2A neurons (mean ± SEM, n = 9 cells/N = 5 mice; one sample t-test ***p < 0.001). I Averaged RS102221 + NBOH-2C-CN effects on firing in 5-HT2A neurons (mean ± SEM, n = 10 cells/N = 5 mice; paired t-test **p < 0.01). J Normalized RS102221 + NBOH-2C-CN effects on firing in 5-HT2A neurons (mean ± SEM, n = 10 cells/N = 5 mice; one sample t-test *p < 0.05).

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