Fig. 6: The role of Gαq signaling in the effects of psilocin and NBOH-2C-CN on 5-HT2A neurons. | Translational Psychiatry

Fig. 6: The role of Gαq signaling in the effects of psilocin and NBOH-2C-CN on 5-HT2A neurons.

From: Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation

Fig. 6: The role of Gαq signaling in the effects of psilocin and NBOH-2C-CN on 5-HT2A neurons.The alternative text for this image may have been generated using AI.

A Cartoon depicting extracellular application of FR900359 drug onto recorded neurons. B Representative recording of 5-HT2A neuron firing after FR900359 (1 µM) and psilocin (10 µM). C Averaged FR900359 effects on firing in 5-HT2A neurons (mean ± SEM, n = 10 cells/N = 4 mice; paired t-test **p < 0.01). D Normalized FR900359 effects on firing in 5-HT2A neurons (mean ± SEM, n = 10 cells/N = 4 mice; one sample t-test **p < 0.01). E Averaged FR900359 + psilocin effects on firing in 5-HT2A neurons (mean ± SEM, n = 10 cells/N = 4 mice). F Normalized FR900359 + psilocin effects on firing in 5-HT2A neurons (mean ± SEM, n = 10 cells/N = 4 mice). G Representative recording of 5-HT2A neuron firing after FR900359 (1 µM) and NBOH-2C-CN (200 nM). H Averaged FR900359 effects on firing in 5-HT2A neurons (mean ± SEM, n = 6 cells/N = 3 mice; paired t-test **p < 0.01). I Normalized FR900359 effects on firing in 5-HT2A neurons (mean ± SEM, n = 6 cells/N = 3 mice; one sample t-test **p < 0.01). J Averaged FR900359 + NBOH-2C-CN effects on firing in 5-HT2A neurons (mean ± SEM, n = 7 cells/N = 3 mice). K Normalized FR900359 + NBOH-2C-CN effects on firing in 5-HT2A neurons (mean ± SEM, n = 7 cells/N = 3 mice). L Cartoon depicting intracellular application of FR900359 drug onto recorded neurons. M Representative recording of 5-HT2A neuron firing with FR900359 (1 µM) in internal solution and psilocin (10 µM). N Averaged FR900359 + psilocin effects on firing in 5-HT2A neurons (mean ± SEM, n = 9 cells/N = 5 mice; paired t-test *p < 0.05). O Normalized FR900359 + psilocin effects on firing in 5-HT2A neurons (mean ± SEM, n = 9 cells/N = 5 mice). P Representative recording of 5-HT2A neuron firing with FR900359 (1 µM) in internal solution and NBOH-2C-CN (200 nM). Q Averaged FR900359 + NBOH-2C-CN effects on firing in 5-HT2A neurons (mean ± SEM, n = 8 cells/N = 4 mice.). R Normalized FR900359 + NBOH-2C-CN effects on firing in 5-HT2A neurons (mean ± SEM, n = 8 cells/N = 4 mice).

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