Fig. 4: Mediation of the associations between environmental chemical exposures (ECMs) and depression by endogenous proteins. | Translational Psychiatry

Fig. 4: Mediation of the associations between environmental chemical exposures (ECMs) and depression by endogenous proteins.

From: An interpretable machine learning model predicts the interactive and cumulative risks of different environmental chemical exposures on depression

Fig. 4

A The mediation effects of environmental chemical exposures (ECMs) on depression via various endogenous proteins. The x-axis represents different ECMs, while the y-axis represents the mediation effect, which is quantified as a percentage. Only significant mediation effects with a threshold of P < 0.05 are included. B Mediation network between ECMs and endogenous proteins. The nodes represent ECMs and internal proteins, while the edges (connecting lines) indicate significant mediation pathways. FPG fasting plasma glucose, HbA1c hemoglobin A1c, Alt alanine aminotransferase, AST aspartate aminotransferase, TBIL total bilirubin, ALP alkaline phosphatase, TP total protein, ALB albumin, GLB globulin, CRE creatinine, UA uric acid, BUN blood urea nitrogen, TG triglycerides, TC total cholesterol, HDL high-density lipoprotein, LDL low-density lipoprotein, LDH lactate dehydrogenase.

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