Fig. 4: Deep Brain Stimulation Reshapes Microstate Transition Dynamics.
Chord diagram illustrating microstate transition probabilities during the DBS-On and DBS-Off phases. Arrows indicate the direction of transition. Red signifies a significantly higher transition probability in the DBS-On phase compared to DBS-Off (pFDR < 0.05), while blue indicates the opposite (significantly lower probability in DBS-On, pFDR < 0.05); gray denotes non-significant differences between phases. Key significant changes include increased transition probabilities for A ⇋ C, B → A and E → B, and a decreased probability for C ⇋ D during the DBS-On phase. Statistical details (Paired t-test, n = 10, DBS-On versus DBS-Off, mean ± SD): A to B: DBS-On: 0.05 ± 0.02%, DBS-Off: 0.03 ± 0.01%, p = 0.020, pFDR = 0.058; A to C: DBS-On: 0.06 ± 0.02%, DBS-Off: 0.03 ± 0.01%, p = 0.002, pFDR = 0.028, d = 1.39; A to D: DBS-On:0.04 ± 0.01%, DBS-Off: 0.04 ± 0.02%, p = 0.899, pFDR = 0.954; A to E: DBS-On: 0.03 ± 0.01%, DBS-Off: 0.03 ± 0.01%, p = 0.319, pFDR = 0.429. B to A: DBS-On: 0.06 ± 0.02%, DBS-Off: 0.03 ± 0.02%, p = 0.010, pFDR = 0.044, d = 1.03; B to C: DBS-On: 0.07 ± 0.02%, DBS-Off: 0.07 ± 0.02%, p = 0.710, pFDR = 0.828; B to D: DBS-On: 0.05 ± 0.02%, DBS-Off: 0.04 ± 0.01%, p = 0.103, pFDR = 0.212; B to E: DBS-On: 0.04 ± 0.01%, DBS-Off: 0.04 ± 0.01%, p = 0.017, pFDR = 0.054. C to A: DBS-On: 0.06 ± 0.01%, DBS-Off: 0.03 ± 0.01%, p = 0.004, pFDR = 0.028, d = 1.21; C to B: DBS-On: 0.07 ± 0.02%, DBS-Off: 0.07 ± 0.02%, p = 0.632, pFDR = 0.763; C to D: DBS-On: 0.06 ± 0.01%, DBS-Off: 0.12 ± 0.04%, p = 0.004, pFDR = 0.028, d = 1.20; C to E: DBS-On: 0.05 ± 0.03%, DBS-Off: 0.06 ± 0.03%, p = 0.246, pFDR = 0.374. D to A: DBS-On: 0.04 ± 0.01%, DBS-Off: 0.04 ± 0.02%, p = 0.841, pFDR = 0.920; D to B: DBS-On: 0.05 ± 0.02%, DBS-Off: 0.04 ± 0.01%, p = 0.137, pFDR = 0.243; D to C: DBS-On: 0.06 ± 0.01%, DBS-Off: 0.11 ± 0.04%, p = 0.004, pFDR = 0.028, d = 1.21; D to E: DBS-On: 0.04 ± 0.02%, DBS-Off: 0.05 ± 0.02%, p = 0.211, pFDR = 0.336. E to A: DBS-On: 0.03 ± 0.01%, DBS-Off: 0.03 ± 0.01%, p = 0.204, pFDR = 0.336; E to B: DBS-On: 0.04 ± 0.01%, DBS-Off: 0.03 ± 0.01%, p = 0.013, pFDR = 0.046, d = 0.97; E to C: DBS-On: 0.05 ± 0.03%, DBS-Off: 0.06 ± 0.03%, p = 0.294, pFDR = 0.429; E to D: DBS-On: 0.04 ± 0.01%, DBS-Off: 0.05 ± 0.02%, p = 0.137, pFDR = 0.243.
