Fig. 5: Microstate Changes Correlate with Clinical Symptom Severity. | Translational Psychiatry

Fig. 5: Microstate Changes Correlate with Clinical Symptom Severity.

From: Therapeutic deep brain stimulation targeting BNST-NAc circuit driven large-scale brain networks in treatment-resistant depression

Fig. 5: Microstate Changes Correlate with Clinical Symptom Severity.

A Heatmap of Spearman correlation coefficient matrix between coverage and occurrence of microstate A and B, and HAMA (top) or HAMD (bottom) scores. (Spearman correlation, n = 10, for HAMA: coverage of microstate A, r = −0.413. p = 0.07; occurrence of microstate A, r = −0.497, p = 0.026; coverage of microstate B, r = −0.392, p = 0.087; occurrence of microstate B, r = −0.492, p = 0.027; for HAMD: coverage of microstate A, r = −0.363. p = 0.116; occurrence of microstate A, r = −0.426, p = 0.061; coverage of microstate B, r = −0.364, p = 0.115; occurrence of microstate B, r = −0.457, p = 0.043). B Heatmap of Spearman correlation matrix between transition probabilities of microstate A ⇋ C, C ⇋ D, B → A and E → B and HAMA (top) or HAMD (bottom) scores. (Spearman correlation, n = 10, for HAMA: A to C, r = −0.642, p = 0.002; B to A, r = −0.375, p = 0.104; C to A, r = −0.632, p = 0.003; C to D, r = 0.744, p < 0.001; D to C, r = 0.751, p < 0.001; E to B, r = −0.58, p = 0.007; for HAMD: A to C, r = −0.496, p = 0.026; B to A, r = −0.273, p = 0.244; C to A, r = −0.496, p = 0.026; C to D, r = 0.731, p < 0.001; D to C, r = 0.77, p < 0.001; E to B, r = −0.688, p < 0.001). Spearman’s rho of each correlation is displayed. * Uncorrected p < 0.05.

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