Fig. 7: NAc gamma aperiodic activities driven transitions of microstates.

A Schematic illustration depicting the whole-brain transition from microstate C to microstate D. B Raw trace of the 0.5–100 Hz filtered LFP signal recorded from the NAc, spanning 500 ms centered on the transition point from microstate C to microstate D. C Spectrogram of the NAc LFP signal corresponding to the data in (B), centered on the microstate C to D transition time point. An enhancement in gamma band activity is evident, initiating approximately 60 ms prior to the transition onset and persisting throughout the transition period. D Averaged peri-event spectrogram across 54 microstate C to D transition trials (recorded from 10 patients). Each trial’s spectrogram covers the 1–100 Hz frequency range. Pronounced high-frequency activity is evident surrounding the transition time point. E Comparison of gamma band power between the 50 ms interval preceding and the 50 ms interval succeeding the microstate C to D transition (n = 54 trials from 10 patients). Statistical analysis performed using a paired t-test; results are indicated within the figure panel. F Comparison of the gamma band aperiodic component between the 50 ms interval preceding and the 50 ms interval succeeding the microstate C to D transition (n = 54 trials from 10 patients). Statistical analysis performed using a paired t-test; results are indicated within the figure panel. G Averaged peri-event spectrogram across 47 microstate D to C transition trials (recorded from 10 patients). Each trial’s spectrogram covers the 1–100 Hz frequency range. H Comparison of gamma band power between the 50 ms interval preceding and the 50 ms interval succeeding the microstate D to C transition (n = 47 trials from 10 patients). Statistical analysis performed using a paired t-test; results are indicated within the figure panel. I Comparison of the gamma band aperiodic component between the 50 ms interval preceding and the 50 ms interval succeeding the microstate D to C transition (n = 47 trials from 10 patients). Statistical analysis performed using a paired t-test; results are indicated within the figure panel.