Fig. 1: Decreased levels of 18-F FDG SUVmean for WB, AMG, HIPP, and VPC metabolisms were independently correlated with incident depression.

A Changes of brain regional metabolic values from baseline to remission in patients of discovery cohort with future onset of depression and control, shown as mean values ± 95% confidence interval. B Univariate analysis of depression onset risk associated with clinic-pathological variables and brain regional metabolic values in Cox proportional hazard model. C Multivariate analysis of depression onset risk associated with significant variables found in univariate analysis in the Cox proportional hazard model.