Table 1 Summary of observations of anti-CASPR2 antibodies and their respective isotype control.
From: Heterogeneity of anti-Caspr2 antibodies: specificity and pathogenicity
Antibody | Adult brain slices (PFA) | Adult brain slices (snap frozen) | E15.5 sections | Primary neuronal culture | HEK cell based assay (M=mouse) (H=human) | Caspr 2 domain specificity | Behavior | Dendritic Length |
|---|---|---|---|---|---|---|---|---|
P11G7 (IgG1) | Yes | Yes | Yes | Yes | Yes (M/H) | discoidin | No phenotype | No differences |
P9C7 (IgG1) | No | Yes | Yes | No | Yes (M/H) | discoidin | Reduced social interaction Reduced time in center in open field task | No differences |
P13F4 (IgG2b) | Yes | Yes | Yes | Yes | Yes (M/H) | Reduced time in center in open field task Hyperactivity | No differences | |
P6B2 (IgG2b) | Yes | Yes | No | Yes | Yes (M/H) | None | Reduced social interaction | |
P3.6.2.8.1 (IgG1 control) | No | No | No | No | No | None | ||
MPC11 (IgG2b control) | No | No | No | No | No |
