Fig. 1: Development of the epileptic mouse model via intrahippocampal kainic acid (KA) injection.
From: Upregulation of CCK3R leading to the suppression of chronic seizures
A Schematic illustration of the intrahippocampal KA injection-induced epileptic mouse model. B Mice movement recognition system (MMRS). C Seizure occurrences in eight mice (after KA injection) without therapy. Each dot represents one seizure event. The y-axis represents the observation time over 24 h. D The survival rate of eight mice with chronic epilepsy. E Averaged daily seizures each week over 16 weeks (N = 5, one-way ANOVA with Tukey’s post hoc test, *P < 0.05; N.S.). F Immunohistochemistry images and group data for staining of glial fibrillary acidic protein in the chronic epileptic mice (scale bar: 500 µm; n = 10 sections, N = 4 mice; one-way ANOVA with Tukey’s post hoc test, ****P < 0.0001). Data are expressed as mean ± standard error of the mean. ANOVA, analysis of variance; N.S.; not significant.
