Table 2 Group comparisons of surface area, thickness, volume, and mean curvature across 34 cortical regions (each hemisphere) between OCD and healthy controls.

From: Widespread alterations of white matter integrity in medication-free obsessive-compulsive disorder

Cortical Region	Hemisphere	Surface area (p_fdr)		Thickness (p_fdr)		Volume (p_fdr)		Mean curvature (p_fdr)
Banks of superior temporal sulcus	L	0.210		0.792		0.272		0.200
Banks of superior temporal sulcus	R	0.146		0.615		0.104		0.301
Caudal anterior cingulate cortex	L	0.043	↓	0.056		0.099		0.503
Caudal anterior cingulate cortex	R	0.014	↓	0.054		0.138		0.153
Caudal middle frontal gyrus	L	0.070		0.146		0.017	↓	<0.001	↑
Caudal middle frontal gyrus	R	0.001	↓	0.070		<0.001	↓	0.002	↑
Cuneus cortex	L	0.757		<0.001	↓	0.054		0.210
Cuneus cortex	R	0.807		<0.001	↓	0.001	↓	0.215
Entorhinal cortex	L	0.739		0.544		0.693		0.558
Entorhinal cortex	R	0.242		0.034	↓	0.743		0.534
Fusiform gyrus	L	0.188		0.628		0.061		0.633
Fusiform gyrus	R	0.478		0.052		0.043	↓	0.902
Inferior parietal lobule	L	0.257		0.130		0.123		<0.001	↑
Inferior parietal lobule	R	0.150		0.047	↓	0.025	↓	<0.001	↑
Inferior temporal gyrus	L	0.137		0.259		0.365		0.159
Inferior temporal gyrus	R	0.088		0.770		0.060		0.657
Isthmus of cingulate cortex	L	0.482		0.089		0.756		0.502
Isthmus of cingulate cortex	R	0.018	↓	0.043	↑	0.335		0.077
Lateral occipital cortex	L	0.063		0.017	↓	0.002	↓	0.007	↑
Lateral occipital cortex	R	0.089		0.060		0.016	↓	0.001	↑
Lateral orbitofrontal cortex	L	0.959		0.933		0.153		0.001	↓
Lateral orbitofrontal cortex	R	0.227		0.307		0.996		0.004	↓
Lingual gyrus	L	0.585		<0.001	↓	0.002	↓	0.575
Lingual gyrus	R	0.599		<0.001	↓	0.008	↓	0.668
Medial orbitofrontal cortex	L	0.215		0.043	↑	0.210		0.043
Medial orbitofrontal cortex	R	0.043	↑	0.002	↑	0.044	↑	0.006
Middle temporal gyrus	L	0.302		0.564		0.307		0.011	↑
Middle temporal gyrus	R	0.069		0.959		0.069		0.001	↑
Parahippocampal gyrus	L	0.542		0.859		0.447		0.044	↓
Parahippocampal gyrus	R	0.579		0.766		0.767		0.008	↓
Paracentral lobule	L	0.659		0.272		0.180		0.624
Paracentral lobule	R	0.272		0.419		0.068		0.834
Inferior frontal gyrus, pars opercularis	L	0.011	↓	0.988		0.010	↓	0.480
Inferior frontal gyrus, pars opercularis	R	0.008	↓	0.847		0.002	↓	0.015	↑
Inferior frontal gyrus, pars orbitalis	L	0.003	↓	0.004	↑	0.579		0.579
Inferior frontal gyrus, pars orbitalis	R	0.104		0.012	↑	0.796		0.210
Inferior frontal gyrus, pars triangularis	L	0.306		0.836		0.321		0.529
Inferior frontal gyrus, pars triangularis	R	0.043	↓	0.875		0.043	↓	0.153
Pericalcarine cortex	L	0.948		<0.001	↓	0.053		0.169
Pericalcarine cortex	R	0.447		<0.001	↓	<0.001	↓	0.579
Postcentral gyrus	L	<0.001	↓	<0.001	↓	<0.001	↓	0.047	↑
Postcentral gyrus	R	0.213		0.001	↓	0.002	↓	0.154
Posterior cingulate cortex	L	0.222		0.019	↑	0.569		0.151
Posterior cingulate cortex	R	0.015	↓	0.025	↑	0.060		0.794
Precentral gyrus	L	0.001	↓	0.001	↓	<0.001	↓	<0.001	↑
Precentral gyrus	R	0.022	↓	0.008	↓	<0.001	↓	0.001	↑
Precuneus	L	0.659		0.052		0.104		0.301
Precuneus	R	0.307		0.757		0.077		0.757
Rostral anterior cingulate cortex	L	0.302		0.180		0.503		0.026	↓
Rostral anterior cingulate cortex	R	0.546		0.064		0.544		0.179
Rostral middle frontal gyrus	L	0.001	↓	0.043	↑	0.043	↓	0.004	↑
Rostral middle frontal gyrus	R	0.011	↓	0.015	↑	0.151		<0.001	↑
Superior frontal gyrus	L	0.026		0.227		0.054		0.137
Superior frontal gyrus	R	0.014	↓	0.013	↑	0.053		0.159
Superior parietal lobule	L	0.387		<0.001	↓	0.011	↓	0.151
Superior parietal lobule	R	0.364		<0.001	↓	0.007	↓	<0.001	↑
Superior temporal gyrus	L	0.502		0.122		0.203		0.444
Superior temporal gyrus	R	0.159		0.307		0.077		0.201
Supramarginal gyrus	L	0.043	↓	0.019	↓	0.004	↓	<0.001	↑
Supramarginal gyrus	R	0.020	↓	0.018	↓	0.002	↓	0.043	↑
Frontal pole	L	0.080		0.001	↑	0.427		0.575
Frontal pole	R	0.152		0.279		0.544		0.042	↓
Temporal pole	L	0.497		0.984		0.560		0.623
Temporal pole	R	0.496		0.210		0.073		0.390
Transverse temporal gyrus (Heschl’s Gyrus)	L	0.766		<0.001	↓	0.011	↓	0.485
Transverse temporal gyrus (Heschl’s Gyrus)	R	0.302		<0.001	↓	<0.001	↓	0.542
Insula	L	0.847		0.496		0.257		0.521
Insula	R	0.194		0.856		0.070		0.757

P values were corrected for multiple comparisons using the false discovery rate (FDR) method. Significant results (p_fdr < 0.05) were indicated in bold. ↓ indicates that OCD showed lower values compared to HCs, while ↑ indicates that OCD showed higher values than HCs.
L left hemisphere, R right hemisphere.

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Table 2 Group comparisons of surface area, thickness, volume, and mean curvature across 34 cortical regions (each hemisphere) between OCD and healthy controls.

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