Fig. 4: Significant hallmark pathway regulation one hour after treatment. | Translational Psychiatry

Fig. 4: Significant hallmark pathway regulation one hour after treatment.

From: Response of iPSC-derived neurons from individuals with treatment-resistant depression to (2 R,6 R)-hydroxynorketamine and reelin: an exploratory study

Fig. 4

Delta values indicate direction of change from vehicle treatment, with blue indicating downregulation and red indicating upregulation. At 50 nM, reelin significantly upregulated all pathways displayed. (2 R,6 R)-hydroxynorketamine (HNK) also significantly upregulated epithelial to mesenchymal transition (EMT), hypoxia, and tumor necrosis factor (TNF-α) signaling, and inhibited UV response. No other significant changes in pathways were observed across treatment groups. Bolded values indicate significance, with * p < 0.05.

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