Table 2 Failed Medication Trials for Participants with TRD (n = 5).

From: Response of iPSC-derived neurons from individuals with treatment-resistant depression to (2 R,6 R)-hydroxynorketamine and reelin: an exploratory study

  

Lifetime Total - Failed Medication Trials at Adequate Dose and Duration

 

Overall duration of illness (years)

SSRI trials

SNRI trials

TCA trials

MAOI trials

Other antidepressant trials

Augmentation trials

Mean

24.3

2.3

1.2

1.0

0.3

1.7

3.8

Standard Deviation

16.4

2.2

1.0

1.3

0.5

0.8

3.3

Range

6 - 49

0 - 5

0 - 3

0 - 3

0 - 1

0 - 3

0 - 7

  1. TRD treatment-resistant depression, SSRI selective serotonin reuptake inhibitor, SNRI serotonin-norepinephrine reuptake inhibitor, TCA tricyclic antidepressant, MAOI monoamine oxidase inhibitor.
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