Fig. 4: Rescued CRS aggravating Mitochondrial Dysfunction in the Brain by TSPO Antagonist (PK11195). | Translational Psychiatry

Fig. 4: Rescued CRS aggravating Mitochondrial Dysfunction in the Brain by TSPO Antagonist (PK11195).

From: Critical role of translocator protein (TSPO) in neuronal mitochondrial dysfunction and mental stress-exacerbated ischemic injury following stroke

Fig. 4

A Administration of PK11195 decreased mental-stress-induced upregulation of TSPO. B PK11195 alleviated CRS decreased the activities of mitochondria respiratory complex I/II/III/IV (p < 0.05). C The activities of ATPase (p < 0.05), citrate synthase (p < 0.01), and ATP production (p < 0.01) were rescued upon PK11195. D PK11195 reduced CRS-induced increases in the protein expression of ACBD3 (p < 0.05), PKA (p < 0.001) and CaMK (p < 0.01) upon PK11195. *: CRS vs control. &:control vs PK11195. #: CRS vs CRS + PK11195. Data are presented as mean ± SEM.

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