Fig. 1: Study flow diagram.

OMIM, Online Mendelian Inheritance in Man; PPI, Protein-Protein Interaction; KEGG, Kyoto Encyclopedia of Genes and Genomes; PDB, Protein Data Bank. BC, betweenness centrality; CC, closeness centrality; DC, degree centrality; AKT1, AKT serine/threonine kinase 1; AKT3, AKT serine/threonine kinase 3; CREBBP, CREB-binding protein; EGFR, epidermal growth factor receptor; EP300, histone acetyltransferase p300; INS, insulin A chain; IL-6, interleukin-6; IGF1R, insulin-like growth factor 1 receptor alpha chain; MAPK1, mitogen-activated protein kinase 1; MAPK3, mitogen-activated protein kinase 3; PIK3CA, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; PIK3R1, phosphatidylinositol 3-kinase regulatory subunit alpha; STAT3, signal transducer and activator of transcription 3.